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''Clostridium novyi'' (oedematiens) a Gram-positive, endospore- forming, obligate anaerobic bacteria of the class clostridia. It is ubiquitous, being found in the soil and faeces. It is pathogenic, causing a wide variety of diseases in man and animals. It comes in three types, labelled A, B, and a non-pathogenic type C distinguished by the range of toxins they produce. Some authors include ''Clostridium haemolyticum'' as ''Clostridium novyi'' type D. ''C novyi'' is closely related to ''Clostridium botulinum'' types C and D as Yoshimasa Sasaki et al. have demonstrated by 16S rDNA sequence analysis. Growth in culture proceeds through 3 stages: Initial growth wherein no toxin is produced; vigorous growth wherein toxin is produced; and spore formation wherein endospores are formed and toxin production decreases. It is suggested that type C may be type B that forms spores more readily so does not go through the toxin-production stage. Isolating and identifying ''C novyi'' is difficult due to its extreme anaerobic nature. Commercial kits may not be adequate. It is also fastidious and difficult to culture, requiring the presence of thiols. ==Toxins== :The toxins are designated by Greek letters. The toxins normally produced by the various types are shown in table 1 The alpha-toxin of ''Clostridium botulinum'' types C and D, is similar to the ''C novyi'' beta-toxin. The A and B toxins of ''Clostridium difficile'' show homology with the alpha-toxin of ''C novyi'' as does the lethal toxin of ''clostridium sordellii.'' 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Clostridium novyi」の詳細全文を読む スポンサード リンク
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